Ongoing Projects/Programs

ASPIRE Project

The ACTION to Sustain Precision and Integrated HIV Response towards Epidemic Control (ASPIRE) project that we implement is funded by the US President’s Emergency Plan for AIDS Relief (PEPFAR) through the US Centers for Disease Prevention and Control (CDC).

The project is currently focused in four states, Nasarawa State, Rivers State, Kastina State and the Federal Capital Territory. It is aimed at

• Reducing mortality of people living with HIV (PLHIV) by providing services for them to know their HIV status and be linked to quality sustained treatment.
• Improving the quality of life of people living with HIV: 95% of clients identified are to be linked to treatment, be virally suppressed and reduce further transmission including elimination of mother-to-child transmission of HIV.
• Increasing uptake of prevention services including Pre-Exposure Prophylaxis by those at risk especially key population and underserved groups such as adolescents.
• Strengthening laboratory capacity to achieve quality clinical management for HIV and other health challenges.
• Empowering quality health care and sustainable culture of excellence in the management of HIV through Continuous Quality Improvement.
• Strengthening the capacity of the Government of Nigeria for a sustainable HIV program: flowing out of a strengthened health care enterprise is the capacity of the Government of Nigeria to embrace a sustainability plan for leadership, governance, and informed investment in HIV programs.

ASPIRE  project provides the following services in the health facilities we support: HIV Testing Services (HTS), laboratory diagnosis and tracking of status of people living with HIV, prevention of Mother-to-Child Transmission (PMTCT) of HIV, Anti-retroviral Treatment (ART) for adult and children (including pregnant women), care and support for people living with HIV/AIDS and people affected by HIV/AIDS, monitoring and evaluation of patients and program progress, support to Orphans and Vulnerable Children (OVC), gender-Based Violence (GBV) support services and training in all the above areas.

ASPIRE project is follow on project to ACHIEVE (2017-2022), ACTIONPlusUp (2012 -2017), ACTIONPlus (2010-2012) and AIDS Care and Treatment in Nigeria (ACTION) projects (2004 to 2010).

Improving Nigeria’s Capacity to Use Data on Registered Stillbirths for Decision-making & Planning (SPEED Project)

The Bloomberg Philanthropies Data for Health (D4H) Initiatives Global Grants Program has sub-awarded the Institute of Human Virology Nigeria – International Research Centre for Excellence (IHVN-IRCE), to implement the SPEED Project; a 15-month project aimed at using Nigeria’s stillbirths’ data to influence decision-making. Click here to learn more

The USAID/Nigeria Tuberculosis Local Organization Network (TB-LON) project seeks to rapidly find and treat people infected with tuberculosis. Click for more

PrEP is a pill that is taken once a day and helps prevent HIV infection.

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Global Fund to Fight AIDS, Tuberculosis and Malaria Grant Cycle 7 (GC7) Project

The Institute of Human Virology, Nigeria (IHVN), funded by The Global Fund to Fight AIDS, Tuberculosis and Malaria, is set to implement the Grant Cycle 7 (GC7) grant. This combined effort for tuberculosis (TB) and HIV is pivotal for the transformation of TB and HIV programs. Under the guidance of the National AIDS and STDs Control Programme (NASCP), the National TB and Leprosy Control Programme (NTBLCP), and the National Agency for the Control of AIDS (NACA), this project aims to increase the identification of all forms of TB in both the private sector and the community.

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This project is aimed at upgrading the infrastructure and functions of the Institute of Human Virology Nigeria (IHVN) central bio-repository in Abuja to international standards.

With the grant funded by the National Institutes of Health, the IHVN Human Heredity and Health in Africa (H3 Africa) biorepository (IHAB) supports H3Africa investigators in Africa to conduct high-quality genomics and translational research.

IHAB ensures well-processed, preserved and quality controlled and protected human biological samples for genomic and other bio-medical studies to address health issues and diseases in the African continent.

Principal Investigator is Prof. Alash’le Abimiku, IHVN Executive Director, International Research Center of Excellence.

For more information, contact, www.i-hab.org

IAS CIPHER CaPS Study

The Impact of Structured Caregiver Peer Support (CaPS) on ART Adherence and Viral Suppression among Children Living with HIV in Nigeria project is a two-arm cluster randomized controlled trial.

The study involves 132 children living with HIV whose HIV viral load is unsuppressed and their caregivers. Six cluster health facilities are involved in this research which will,

• Explore facilitators and barriers to Antiretroviral Treatment (ART) adherence among young children. This will guide the development of a caregiver peer mentor training curriculum and interventional programme.
• Test the impact of caregiver peer support in improving adherence and promoting achievement of viral suppression among children.

The intervention will target caregivers of unsuppressed children (0-10years), measuring outcomes at child level after 6, 12 and 18 months of follow up.

The intervention arm will receive structured caregiver-to-caregiver peer support while the control arm will receive routine standard of care with no such support.

We are a member of the PhArmacoVigilance Africa (PAVIA) consortium aimed at strengthening pharmacovigilance in four African countries namely Ethiopia, Nigeria, Swaziland and Tanzania. The consortium is funded by the European Developing Countries Clinical Trial Images Partnership (EDCTP).

To improve pharmacovigilance, the project is strengthening routine reporting of drug adverse events amongst other activities. We will also be carrying out research, training health care workers across the country on pharmacovigilance, and developing necessary guidelines.

The D2EFT study is a phase IIIB/IV randomised open-label trial to compare dolutegravir with pharmaco-enhanced darunavir versus dolutegravir with predetermined nucleosides versus recommended standard of care antiretroviral regimens in patients with HIV-1 infection who have failed recommended first line therapy.

The major aim of this study is to find the best 2nd line regimen, among the current range of drugs used in our environment that would have maximal benefit for most patients who have failed first line HIV 1 drugs.

This is without the infrastructure of drug sensitivity testing in a resource constrained environment. Its emphasis is finding a regimen that will fulfil criteria including:

• Efficacy at significantly reducing viral load
• Encouraging adherence due to a lower incidence of drug toxicity, drug to drug interactions or other adverse events,
• Improving participant quality of life

The D2EFT study is designed to support HIV treatment in the sub-Saharan African context and will provide knowledge to significantly improve treatment outcomes and change the current strategy for managing patients who have failed 1st line HIV treatment.

Building TRUST Study is a follow-on study to the TRUST study. TRUST study, an implementation science research grant, uncovered high-risk men who have sex with men (MSM) with a high HIV prevalence (44%) and low uptake of clinical care and treatment. These men also have low levels of disclosure of HIV and/or sexual orientation, high incidence rates of both HIV infection (13.9 per 100 person- years) and sexually transmitted infections (STI) (gonorrhea and chlamydia).

Building TRUST study suggests that there are interventions to address interpersonal, network and structural barriers to HIV treatment and prevention. It is framed in the 2014 WHO Consolidated Guidelines on HIV Prevention, Diagnosis, Treatment and Care for Key Populations.  The aims the study include, investigating the impact of introducing Pre-exposure Prophylaxis (PrEP) and characterizing HIV transmission networks within the MSM community. This is to lead to interventions to prevent HIV transmission.

The goal of the Impact of Non-B HIV-1 Subtype on second-line Protease Inhibitor Regimens in Africa (INSPIRE) project is to identify factors that predict virological failure among patients with Protease Inhibitor (PI) containing regimens. These patients however, have no resistance using the conventional drug resistance testing assay, and are infected with wide range of HIV subtypes in Cameroon, Uganda, South Africa and Nigeria.  Findings from this study will provide further understanding on resistance to HIV drugs and inform National and International HIV/AIDS Treatment Guidelines.

Collaborators:  Miguel E. Quiñones-Mateu, Ph.D. Professor, Webster Family Chair in Viral Pathogenesis, Associate Dean Research, Department of Microbiology & Immunology, School of Biomedical Sciences

University of Otago, New Zealand

Bob Shafer, MD Division Infectious Diseases, Department Medicine, Stanford University, US

Eric O. Freed, PhD HIV Dynamics and Replication Program, NIH/NCI

This study examines awareness about Pre-Exposure Prophylaxis and willingness to use it among Men who have Sex with Men (MSM). The study, which is part of the PEPFAR Nigeria program to expand use of PrEP, has run from March 2017 till date.

Findings so far have shown that, prior discussion with healthcare workers about PrEP was significantly associated with increased PrEP awareness. Having a larger sexual network was associated with decreased PrEP awareness.  Also, feeling ashamed/embarrassed to use PrEP was associated with decreased willingness to use it. Most MSM in this cohort had no prior knowledge of PrEP. Perceived stigma associated with PrEP use may impact its uptake within this vulnerable community. Efforts, potentially through network interventions, are needed to educate and destigmatize PrEP use to reduce HIV transmission.

This study plans to identify, and characterize the burden of Non-Communicable Diseases among clients newly diagnosed with HIV while capturing the risk factors that individuals may be exposed to. Study objectives are;

1. To measure the prevalence and incidence of non-communicable disease such as hypertension, diabetes, cancers and chronic respiratory diseases among a cohort of clients diagnosed with HIV.
2. To characterize and explore clinical, behavioral and psychosocial risk factors of non-communicable diseases among HIV positive clients.

• To assess participants retention rates and willingness to participate in future HIV prevention and cure research

The study is funded by ISN Products Nigeria Ltd with Professor Alash’le Abimiku as Principal Investigator.

The Vaccination for Recovered In-patients with COVID-19 (VATICO) study is a phase 4 open-label trial which will be

• Investigating the difference in antibody level to mRNA (Moderna or the Pfizer BioNTech) in study participants vaccinated early vs. those vaccinated later.
• Estimating the difference in antibody level in patients vaccinated once vs. those vaccinated twice.

Findings from the VATICO study will be useful in determining the usefulness of vaccination in people who have recovered from COVID-19 considering that they would have acquired immunity from the infection. The study will also provide scientific evidence to inform vaccination guidelines for patients who recover from COVID 19 infection.

It will enroll patients under the ACTIV-3/TICO parent study who receive investigational drugs and have achieved sustained recovery from the COVID-19 infection.

The VATICO study will be implemented in collaboration with the University of Abuja Teaching Hospital Gwagwalada (UATH).  Dr. Eriobu Nnakelu is the Nigerian Principal Investigator while Drs. Vivian Kwaghe and Habid Zaiyad are co-investigators.

Study duration is from 16 to 24 months and funding for the study is from the National Institute of Allergy and Infectious Diseases (NIAID).

EXPAND Project

Expanding the Pool of Independent Investigators in Implementation Science in Nigeria through HIV Research training – EXPAND Nigeria: Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (EXPAND)

EXPAND Nigeria seeks to increase local expertise in responding to Nigeria’s HIV epidemic by addressing research leadership gaps among investigators, program evaluation and knowledge translation gaps among implementers and policymakers.

The study aims are:

Aim 1: To launch a 12-month, soft and hard skills Implementation Science-integrated HIV research training curriculum at the International Research Center of Excellence of the Institute of Human Virology, Nigeria, delivered on a hybrid virtual and in-person platform.

Aim 2: To mentor and develop a cohort of five early career MD and/or PhD scientists trained with the Aim 1 curriculum, to compete for independent research funding that addresses HIV research priorities relevant to Nigeria.

Aim 3: To transition skilled early career investigators from Aim 2 into active and productive research positions at the International Research Center of Excellence of the Institute of Human Virology, Nigeria and collaborating academic and public health institutions in Nigeria.

Aim 4: Using the hard skills modules from the Aim 1 curriculum, provide short-term, six-month training for a multidisciplinary cohort of 40 program implementers and policymakers to design and conduct IS-informed priority HIV program evaluations and translate evidence into policy and practice.

The project, which is funded by the US National Institutes of Health,  runs from 2022 to 2027.

INFORM Africa

The Role of Data Streams in Informing Infection Dynamics in Africa (INFORM Africa) is aimed at establishing data streams from public and private sectors to understand the multi-layer interactions that may explain the dynamics and impact of COVID19 pandemic. This is to be achievement through three proposed research projects and two proposed cores, supplemented by the pilot projects.

Project objectives include:

• Development of geospatial tools for use by country leadership and governments in pandemic surveillance and response to improve preparedness.
• Expansion of data science research opportunities and capacity through the engagement with the broader Data Science for Health Discovery and Innovation in Africa (DS-I-Africa) and through several proposed pilot projects in data science.
• Maintenance of sustained engagement with the policy makers and governments to promote further open access to high quality data, redistribution and uptake of any product/tool developed by the INFORM Africa.

Study countries are, Nigeria, South Africa and Zambia and the duration of study is from 2022 to 2026.

TRiAD Study

Triage Test for All Oral DR-TB Regimen (TRiAD) study is a non-randomized interventional phase 4 (clinical access protocol) implementation science study. It is to evaluate the effectiveness, operational feasibility, acceptability, and cost-effectiveness of implementing the Xpert MTB/XDR assay for rapid triage and selection of all oral regimens for Drug-Resistant Tuberculosis.

The project study facilities are in the Federal Capital Territory, Lagos, Nasarawa, Plateau, Kano and Kaduna states. The study is funded by EDCTP with Dr, Kogieleum Naidoo and Prof. Alash’le Abimiku as Principal Investigators.

BEGET

The BEGET- Diagnostic Thresholds for Diabetes and Prediabetes in HIV infected is to identify appropriate HbA1c and fructosamine diagnostic thresholds for diabetes and prediabetes, based on strata of hemoglobin and other biomarker levels, among persons living with HIV (PLHIV).

Findings from the BEGET study are expected to inform the development of guidelines for the optimal use of glycated testing tools among PLHIV. Successful deployment of these at HIV care and treatment settings will enhance screening and early detection of diabetes and prediabetes in this population. The research is being conducted at the University of Abuja Teaching Hospital.

Principal Investigator: Dr. Jibreel Jumare

Project Funders and collaborators: NIH/UMB

Project Duration: 2023-2025

STRIVE

The Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE) project is a randomized, placebo-controlled clinical trial seeking to evaluate the clinical efficacy of the antiviral drug Ensitrelvir when given in addition to the standard of care for hospitalized patients with COVID-19. The research to provide alternative and more effective treatment for the management of moderate to severe COVID-19.

Over 30 countries are participating in the study – IHVN in collaborating with two sites (University of Abuja Teaching Hospital Gwagwalada and Nisa-Garki Hospital, Garki, Abuja) representing the Nigerian site.

Global Principal Investigator : Prof Jens Lundgren, Nigerian Principal Investigator: Dr Nnakelu Eriobu Co-Investigators: Dr Onu Adamu and Dr Vivian Kwaghe

Project Funders and collaborators: NIH

Project Duration: 2023-2028

VERDI Consortium MPox Research Project

IRCE-IHVN has a VERDI sub-award to contribute Nigerian data to a global pediatric mpox registry, conduct qualitative studies on mpox in the Nigerian context, and to develop research tools and a master protocol for an observational study of mpox among pregnant women in Nigeria. This study seeks to preempt future infectious disease outbreaks by consolidating pandemic preparedness measures. Given its track record of impactful infectious disease research, the International Research Centre of Excellence (IRCE) at the Institute of Human Virology, Nigeria (IHVN) was invited to join the VERDI consortium in 2022.

The European Union-funded VERDI Consortium comprises nearly 30 teams of researchers from 16 countries in Europe, Africa, North America, the Caribbean, the Middle East, and Southeast Asia (https://verdiproject.org/consortium/).

The VERDI country Principal Investigator for Nigeria is Dr. Nadia A. Sam-Agudu,

CAMP Project

The Canada-Africa Monkeypox Partnership (CAMP) is aimed at characterizing transmission dynamics and evaluating medical countermeasures to inform the clinical and public health response to m-pox. CAMP project is a twining study between Nigeria and Canada. This study is being jointly carried out by both countries.

Project objectives in Nigeria include to:

• Characterize and compare Mpox transmission dynamics and serologic histories across epidemic contexts.
• Do formative research on readiness for trials of MPX therapeutics/vaccines in Nigeria and
• To determine MPX vaccine acceptability among adults in Nigeria

The Nigerian team comprises of four institutions that are collectively responsible for the implementation and attainment of the specific aims of the study. These are the Nigeria Institute of Medical Research (NIMR), Institute of Human Virology Nigeria (IHVN), Slum and Rural Health Initiative Nigeria (SRHIN), and the University of Ilorin (UNILORIN).  Cohort 1 of the CAMP project is being implemented in Abuja, Bayelsa, Delta and Lagos States, while Cohort 2 is being implemented in Abuja and Lagos.

Amongst other things, understanding Mpox Transmission Dynamics in Nigeria should lead to the

• Development of targeted public health interventions that can lead to more effective prevention and control strategies, reducing the incidence of Mpox.
• Optimized diagnostic yield to enhance the capacity for early detection and surveillance of Mpox.
• Contributing to the scientific knowledge of the understanding of Mpox transmission in the Nigerian population and providing a foundation for future research on Mpox in Nigeria.
• Building local capacity and strengthening the healthcare infrastructure to better handle future outbreaks of Mpox and other infectious diseases.
• Community engagement and education efforts as part of the study to raise awareness about Mpox transmission, symptoms, and prevention
• Empowerment of At-Risk Populations, such as sexual gender minority communities, in the research process to actively participate in efforts to control and prevent Mpox thereby fostering a sense of ownership and responsibility.

Principal Investigator: Dr. Darrell Tan,

Co-Investigators: Dr. Evaezi Okpokoro, Dr. Ezenwa James Onyemata

Project Funders and collaborators: CIHR/IDRC

Project Duration: 2023-2024

Hepatitis B PROJECT

The Human Genetic determinants of HBV recovery (Hepatitis B Project) is investigating the host genetic basis or human genetics determinants for spontaneous recovery from Hepatitis B Virus (HBV). The project is to ascertain the proportion of Nigerian women who are Hepatitis B and C positive who might be asymptomatic and advise/link them to go for treatment and create awareness for Hepatitis B disease and the need for screening and vaccinations while unravelling the human genetics determinants for spontaneous recovery from Hepatitis B Virus.

It is being implemented in the Federal Capital Territory, Abuja and Nasarawa state. The Principal Investigator is Prof Clement Adebamowo and the Nigerian Principal Investigator is Mr Ayo Famooto

The project is funded by NIH/ John Hopkins and the project’s duration is from 2022-2025.

RISE

The Resilient HIV Implementation Science with Sexual and Gender Minority Youths using Evidence (RISE) project intends to adapt the HMP app towards improving HIV Prevention and Care among the Sexual and Gender Minority (SGM) youth aged 15-24. It focuses on improving utilization of Pre-Exposure Prophylaxis and Antiretroviral Treatment specifically targeting young men who have sex with men (YMSM) and young transgender women (YTW). RISE is a multi-country study with implementation presence in Nigeria, Zambia, Kenya, and Malawi.

The project objectives include:

• Coordinating collaborative coalition between clinical research performing sites (CRPSs), community-based HIV service providers (CBSPs), youth advisory boards (YABs), and health ministries to maximize reach.
• Adapt the HMP app and assess system-level readiness to integrate HMP, a digital health intervention to address the PHCC among SGM youth, guided by the Consolidated Framework for Implementation Research (CFIR).

The study is a Phase III randomized control trial utilizing a Type 2 effectiveness-implementation hybrid design. A total of 750 participants will be randomly assigned to the HMP exposure while the other 750 participants will have delayed access to HMP. The study will enroll a total of 1,500 eligible participants within 24 months, and the randomization will occur at study enrollment.

NORA Study

The Network for Oncology Research in Sub-Sahara Africa (NORA Study) aims to contribute to reducing the mortality of Breast Cancer and Cervical Cancer in partner countries through research, capacity building, networking, policy engagement, and research transfer.

In Nigeria, the focus is on research, capacity building, and networking. In research, the project is committed to establishing evidence-based breast cancer and cervical cancer screening and treatment pathways applicable in sub-Saharan Africa.

In the area of capacity building, the project involves opinion leaders, and policymakers in fostering women’s decision to seek cervical cancer and breast cancer screening. It is also using rapid ethnographic and action approaches (REAP) to understand what determinants underly the intention to seek screening among women using an integrated behavioral model with culture and stigma domain determinants.

Another area under the work package of capacity building is designing and implementing a context-adaptable intervention and evaluating the feasibility, adoption, and sustainability of the interventions.  The study will undertake a qualitative systematic review of literature to identify the personal and health system needs of family caregivers of cancer patients at end-of-life in the home setting. It will provide evidence for the integration of Indigenous and local community resources and infrastructure into cancer-directed palliative care services,  design and implement contextually appropriate palliative care interventions for cancer care and evaluate the feasibility, adoption, and sustainability of the intervention.

In the networking workstream, NORA Study will determine periods from symptom self-detection to first contact with the health system to confirmed diagnosis of suspicious breast lesion. This is to identify modifiable barriers and enablers to early-stage diagnosis. It will explore from different perspectives to improving cervical cancer screening, treatment, and follow-up in primary healthcare clinics.

The NORA consortium involves five countries; Nigeria, Germany, South Africa, Ethiopia, Tanzania, and AFCRN-Lyon (France). In Nigeria, we are implementing in FCT, Rivers and Nasarawa States.  It is funded by GIZ/ German Government.

CAWISA

The Central and West Africa Implementation Science Alliance (CAWISA) is a regional African research consortium established to facilitate research by indigenous scientists of highest standards to solve West and Central Africa’s most pressing public health problems.

CAWISA spans four focus countries: Nigeria, Ghana, Cameroon, and the Democratic Republic of the Congo (DRC). These countries are regional hotspots of adolescent HIV infection, malaria, tuberculosis, viral hepatitis, and non-communicable diseases. They have also experienced recent outbreaks of COVID-19 and Ebola.

The consortium focuses on the following:

• Research productivity and impact: local relevance and applicability of data generated from implementation science research disseminated in several published papers.
• Strategic partnerships with a commitment to fund and carry out research that will drive the adoption of evidence-based practices for improved health outcomes.
• Leadership and vision: dedicated scientific mentorship and demonstrable expertise in implementation science research.
• Scholars & mentors: Engaging individuals committed to scientific advancements, diligent in scholarship and integrity, and willing to continuously pay it forward.
• Sustained funding: Prioritize consistency in pursuing and winning grants to achieve collective goals. CAWISA aims to secure multi-year awards to keep the alliance active and impactful in the West and Central African region and beyond.

For more information, visit http://cawisa-afr.org/

BRILLIANT Study

The International Research Center of Excellence (IRCE) at the Institute of Human Virology Nigeria (IHVN) is a part of the BRILLIANT HIV Vaccine Consortium which is spearheading HIV vaccine development and conducting preclinical studies to determine promising vaccines.

The Bringing Innovation to Clinical and Laboratory Research to End HIV in Africa through New Vaccine Technology” (BRILLIANT) project in Nigeria is to test HIV vaccine concepts and advance the most promising candidates contributing to HIV prevention global efforts. It will strengthen systems of collaborating institutions and countries throughout sub-Saharan Africa while increasing career opportunities for promising regional scientists.

Project methods and research approaches include preclinical and clinical phases comprising immunogen development, animal testing and clinical trial testing in humans. The project has a multi-phasic approach from Phase 1 to Phase 4 starting with low-risk populations as initial participants to test safety and immunogenicity, and progressively and extending to high-risk populations in subsequent phases to assess how well the vaccine protects against infection.

The project is led by the Chief Executive Officer and President of the South African Medical Research Council, Cape Town, South Africa, Prof. Glenda Gray, while the  project’s Principal Investigator in Nigeria is Prof. Alash’le Abimiku.  Project duration is from 2023-2029 and Nigeria, Uganda, Kenya, Tanzania, Zimbabwe, Zambia, Mozambique and South Africa are the participating countries in the project which is funded by USAID.

ENHANCE

The Enhanced and Sustainable Integrated Laboratory Services for HIV, TB, and Other Pathogens in Nigeria (ENHANCE).

ENHANCE supports the Government of Nigeria to reach HIV epidemic control and strengthen its response to HIV, TB, and other diseases of public health significance on a backbone of an optimized centralized laboratory information management system that links data on tracking of sample receipt, testing, generation and return of test results, commodity utilization and tracking, and equipment utilization. Through the utilization of improved and expanded dashboards with real-time or near real-time information, ENHANCE provides laboratory services and system strengthening for

• High quality integrated laboratory diagnostic and surveillance services for TB and HIV diagnosis, HIV test and Early Infant Diagnosis (EID)], monitoring for viral suppression – Viral Load (VL) including Infant Viral Load (IVT), HIV drug resistance and diagnostics of other diseases of public health significance in partnership with the government of Nigeria (GON) and with guidance from Centers for Disease Control and Prevention (CDC)
• Improved coordination, supervision and mentoring by appropriate agencies of the Government of Nigeria and health facilities.
• Expanded internal and external quality assurance processes leading to ISO accreditation of selected CDC-supported molecular laboratories.
• Improved laboratory commodity utilization and monitoring; and
• Improved infection, prevention and control through occupational health, patient safety, and effective waste management at CDC-supported Molecular laboratories.

Project objectives are to implement an integrated molecular diagnostic testing for HIV, TB, and other diseases of public health importance, strengthen laboratory quality management system and External Quality Assurance program, strengthen laboratory biosafety/biosecurity, waste management, Infection Prevention Control and occupational health practices across supported laboratories, enhance and strengthen systems for equipment utilization and efficiency and enhance and strengthen procurement and supply chain management systems.

• Principal Investigator: Alash’le Abimiku
• Project Funders and collaborators: CDC
• Project Duration: 2022-2027
• Places of implementation (states, facilities)- Rivers, Kaduna and Gombe states. Facilities: Rivers State University Teaching Hospital -Rivers State University Teaching Hospital (RSUTH), Ahmadu Bello University Teaching Hospital (ABUTH) and Federal Teaching Hospital (FTH) Gombe.

General Data Sharing Plan (GDSR)

The General Data Sharing Plan (GDSR) project aims to conduct a geospatially targeted malaria

Genomic surveillance at the community level, link and optimize the systems which are currently in place, visualize, assess and operationalize geospatial and temporal genomics surveillance data with other malaria data streams through the REVEAL Geospatial visualization and planning platform.

Akros, Institute of Human Virology Nigeria (IHVN), and West Africa Centre for Cell Biology of Infectious Pathogens (WACCBIP) are collaborating to enable the existing community-level malaria genomic surveillance for detection and response to emerging antimalarial resistance in Ghana.

Through a geo-enabled surveillance system, malaria program managers and researchers in Ghana will be able to visualize mapped patterns of antimalarial resistance, which is currently impossible. GDSR will provide timely access to critical evidence to guide national malaria control programs (NMCP) decision-making for malaria program response and adaptation.

• Principal Investigator: Alash’le Abimiku, Prof. Anna Winters, Prof. Charles Michelo and Prof. Gordon Awandare
• Project Funders and collaborators- NIH
• Project Duration- 2024-2026

This study is to carry out analyses of dried blood spot specimens collected during the Nigeria AIDS Indicator and Impact Survey (NAIIS). NAIIS is one of the largest household surveys ever conducted with over 200,000 respondents. Dried blood spots were collected from more than 205,000 individuals who gave their consent for storage and further testing of these specimens. The study will analyse these specimens using a multiplex bead-based laboratory assay. The multiplex laboratory enables testing for antibody presence for multiple diseases including malaria, vaccine-preventable diseases, neglected tropical diseases, and others in a single test run.

This study is to augment national disease surveillance by supporting the Government of Nigeria to conduct serologic surveillance using specimens stored with consent in the Nigeria Centers for Disease Control (NCDC) National Reference Laboratory sample storage repository. It will also address key knowledge gaps regarding the burden and risk of malaria, vaccine preventable diseases and other diseases of public health importance.

Study objectives include

• Estimate prevalence of malaria in Nigeria to monitor and accelerate procress towards disease control goals
• Estimate sero-prevalence of multiple vaccine preventable diseases in Nigeria to monitor process towards accelerated disease control goals, and identify immunity gaps.
• Estimate seroprevalence of other diseases of public health importance in Nigeria to monitor process towards disease control goals.

Study Principal Investigator is Dr. Sam Peters.

The BEAMING Study is researching into how breast milk affects infant’s gut bacteria and how this in turn affects infant’s growth and their ability to respond to childhood vaccination. This effect will be studied in HIV exposed uninfected children and the results compared with HIV uninfected unexposed children.

It is an NIH funded study that will utilize stored samples from HIV-Exposed Infants in a previous study, the Infant Study.

This study seeks to evaluate the prevalence of malaria parasitemia among blood donors donating blood to children 0-10 years in Abuja, Nigeria. It is funded by the International Society for Blood Transfusion.

This study conducts rigorous research into breast cancer and its molecular subtypes in indigenous population of Nigeria, in order to understand the epidemiological and genomic determinants of the incidence of breast cancer, its molecular subtypes, and the role of diet in etiology of breast cancer in Nigeria.

The TRACING study is a prospective cohort study that is made up of two components. The first component seeks to train health care workers on tuberculosis infection control practices, assess the level of infection control, and measure the output of these trainings. The second component of the study seeks to measure the risk of tuberculosis infections among health care workers.

Aim of the study is to provide evidence to strengthen TB infection control mechanism, and develop policies relevant for protecting health workers.

It is being implemented in at least 14 health facilities across the Federal Capital Territory and Nasarawa States. Facilities were selected based on the availability of HIV and TB services, and the number of patients accessing care in these facilities.

The project uses the Oxford Nanopore, a USB-sized, portable sequencing instrument, to develop a diagnostic assay. This assay rapidly diagnoses patients with acute febrile illness by screening for all potential pathogens in under two hours.

The goal of this five year project is implementation of a field-ready, real-time sequencing assay for unbiased pathogen diagnosis of acute febrile illness using metagenomic nanopore sequencing.

Resolve to Save Lives (RTSL) is an initiative by Vital Strategies aimed at enhancing the capacity and preparedness of low- and middle-income countries to prevent disease outbreaks. Phase I of the RTSL project, launched in 2019, focused on strengthening Quality Management and Specimen Referral Systems in Public Health Laboratories and Networks in Nigeria. This phase was implemented with the Nigeria Center for Disease Control (NCDC) and the Africa Centers for Disease Control and Prevention (ACDC). As a sub-grantee to Vital Strategies, IHVN supported the six Yellow Fever (YF) and two COVID-19 laboratories across six states: FCT, Edo, Enugu, Kaduna, Lagos & Nasarawa. The laboratories involved included the National Reference Laboratory in Gaduwa, Abuja; Central Public Health Laboratory in Lagos; Maitama District Hospital in Abuja; Yusuf Dantsoho Hospital in Kaduna; University of Nigeria Teaching Hospital in Enugu; University of Benin Teaching Hospital in Benin; Nasarawa State Infectious Disease Research Center; and Irrua Specialist Teaching Hospital in Edo.

Phase II of the project began in 2023 to support laboratory governance at the subnational level and improve laboratory quality systems through effective subnational coordination (Laboratory Quality Systems, JEE indicator D1.2). This phase is being implemented with the Medical Laboratory Science Division (MLSD) of the Federal Ministry of Health (FMOH) Federal Ministry of Health ( FMoH-MLS)  across four states: Bayelsa, FCT, Nasarawa, and Kano. Additionally, in partnership with NCDC, it aims to establish and improve national and subnational specimen referral systems for rapid detection of priority pathogens and epidemic-prone diseases.

This study, which is funded by the Bill & Melinda Gates Foundation, is an effort to scale up capacity for integrated sero-surveillance in Africa using stored samples from Nigeria’s HIV/AIDS Indicator and Impact Survey (NAIIS). The objectives of this study are,

1. Support the Multiplex Bead Assay (MBA) laboratory at the Nigeria Centers for Disease Control (NCDC) National Reference Laboratory (NRL) to test stored NAIIS specimens and to collect, store and analyse results.
2. Support technical assistance and capacity building efforts on the MBA technology, and develop a set of tools to assist other countries embarking on integrated surveillance.

• Support dissemination of results and availability of data to inform public health programming in Nigeria.

The European and Developing Countries Clinical Trial Partnership (EDCTP)-Special Program for Research and Training in Tropical Diseases (TDR) Clinical Research and Development Fellowship is a 21-month fellowship program. It is aimed at strengthening the overall capacity of fellows to conduct Clinical Research Implementation including clinical trial studies. The program is structured into three main components: preparatory, training and re-integration phases. The training phase requires that fellows spend 12 months at a European host Institution and thereafter return to their home Institutions for a re-integration phase to build further capacity. For this fellowship, Dr. James Onyemata spent 12 months at the European Vaccine Initiative (EVI). EVI is a not-for profit organisation based in Heidelberg, Germany, and plays a leading role towards the establishment of effective, accessible and affordable vaccines against neglected and tropical diseases.

This Positive Peer-to-Peer (3P) US National Institutes of Health (NIH) study on Adolescents living with HIV (ALHIV) in Nigeria will enable partnership with 16 health facilities with high proportions ALHIV. It will examine the effectiveness and impact of using a WhatsApp® group to deliver structured, on-demand continuing education and real time mentoring for ALHIV peer educators in Nigeria.

Our pilot study revealed that a WhatsApp® platform could be a readily accessible, cost-efficient, complementary medium for mentoring and educating adolescent lay workers in clinics and communities. This is because they provide psychosocial support and linkages for their peers and families. This grant will expand the access of adolescents to the group and help to overcome sociocultural, geographic and security barriers associated with traditional face-to-face or telephone mentoring in Nigeria.

Study Principal Investigator is Dr. Emilia Iwu.

The Therapeutics for Inpatients with COVID-19 (TICO) study is a follow up on the In-patient Treatment with Anti-Coronavirus Immunoglobulin (ITAC) study, which was also implemented by the Institute of Human Virology Nigeria (IHVN). TICO is a master protocol to evaluate the safety and efficacy of multiple drugs aimed at modifying the human immune response to SARS-CoV-2 infection, or directly improving viral control in order to limit disease progression.

TICO is a randomized, blinded, controlled study which allows multiple drugs to be tested during the course of the study. This allows for efficient testing of new drugs against placebo and standard of care (SOC) treatment within the same study. An independent Data and Safety Monitoring Board (DSMB) will regularly review interim analyses and summarize safety and efficacy results to delineate which drug(s) are beneficial for the treatment of COVID 19 symptomatic disease.

The primary aim of this study is to evaluate patients who experience sustained recovery from the time after receiving the investigational drug. This study is being implemented in Africa by the International Research Center of Excellence of the Institute of Human Virology Nigeria collaborating with the University of Abuja Teaching Hospital Gwagwalada (UATH) and the Nigerian COVID-19 Research Consortium (NCRC). TICO is funded by the US National Institute of Allergy and Infectious Diseases (NIAID) with the National PI as Dr Eriobu Nnakelu.C.

Ensuring Quality Access and Learning for Mothers and Newborns in Conflict-Affected Contexts (EQUAL) is a multi-country research project aimed at improving maternal and newborn health in conflict-affected countries.

Institute of Human Virology Nigeria (IHVN) is participating in this research which is funded by UK Aid from the UK government and led by the International Rescue Committee. Other EQUAL partners are Johns Hopkins Bloomberg School of Public Health, and its university-wide Center for Humanitarian Health, the Somali Research and Development Institute, and Université Catholique de Bukavu (Democratic Republic of Congo).

The project is aimed at identifying and filling evidence gaps that could ultimately improve policies, programming, and outcomes for mothers and newborns. It will focus its research around the day of birth and the first week of life — the timeframe with the highest number of newborn deaths globally.

In Nigeria, IHVN is conducting a five-year assessment of the recently implemented Community Midwifery program to examine the effectiveness of midwives in addressing gaps in maternal and neonatal health within rural communities of Yobe State. Of particular interest are factors affecting the midwifery workforce, participation, retention, performance, and personal resilience during periods of increased insecurity

The project is in collaboration with the Nursing and Midwifery Council of Nigeria, National Association of Nigerian Nurses and Midwives, the Government of Yobe State and Faculty of Shehu Sule College of Nursing and Midwifery